PSP: “new concepts” – summary article

This nice summary article, “Progressive supranuclear palsy: new concepts,” is available online at no charge. It reviews the all of the clinical subtypes of PSP, including the two most common types (Richardson’s Syndrome and PSP-Parkinsonism). A photo of a PSP patient with retrocollis is shown.

Given my advocacy for brain donation, I found these points interesting: “[L]ess than a half of patients with pathologically-proven PSP will have received the diagnosis of PSP at presentation. The National Institute of Neurological Disorders and Stroke/ Society for PSP (NINDS/SPSP) criteria detect only 50-70% of patients within 3 years of disease onset.”

Let me know if anything caught your eye.

Here’s a link to the full article: … so&tlng=en

If this link doesn’t work for you, then go to and type 21243256 into the search box. Then an abstract will appear along with a logo. Click on the logo to get the article.


Arquivos de Neuro-Psiquiatria. 2010 Dec;68(6):938-46.

Progressive supranuclear palsy: new concepts.

Barsottini OG, Felício AC, Aquino CC, Pedroso JL.
Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, SP, Brazil.

Progressive supranuclear palsy (PSP) is a distinctive form of neurodegenerative disease which affects the brainstem and basal ganglia. Patients present supranuclear ophthalmoplegia, postural instability and mild dementia. PSP is defined neuropathologically by the accumulation of neurofibrillary tangles in the subthalamic nucleus, pallidum, red nucleus, substantia nigra, striatum, pontine tegmentum, oculomotor nucleus, medulla and dentate nucleus. Over the last decade many lines of investigations have helped refine PSP in many aspects and it is the purpose of this review to help neurologists identify PSP, to better understand its pathophysiology and to provide a more focused, symptom-based treatment approach.

PubMed ID#: 21243256