Combo CoQ10 + creatine – neuroprotective in PD mouse model

This announcement about an animal study in PD that showed that a combo of CoQ10 and creatine produced “neuroprotective effects” was posted today on the Parkinson Forum.

Dear Friends, the following is interesting, but bear in mind that it is an animal study, and it’s too early to say whether it will apply to humans. Nonetheless, it may be of interest to some.

Kathrynne Holden, MS, RD


Coenzyme Q10 and Creatine Show Potential in the Treatment of Neurodegenerative Diseases

Reference: “Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson’s and Huntington’s diseases,” Yang L, Calingasan NY, et al, J Neurochem, 2009; 109(5): 1427-39. (Address: M. Flint Beal, MD, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, F610, New York, NY 10021, USA. E-mail: [email protected] ).

Summary: In a study involving a mouse model of Parkinson’s disease, a rat model of Huntington’s disease and a transgenic mouse model of Huntington’s disease, administration of coenzyme Q10 and creatine in combination was found to produce additive neuroprotective effects. Specifically, administration of the 2 agents was found to protect against dopamine depletion in the striatum and loss of tyrosine hydroxylase neurons in the substantia nigra pars compacta. In addition, significant reductions in lipid peroxidation and pathologic alpha-synuclein accumulation in the SNpc neurons was found, as well as reductions in striatal lesion volumes. The treatment was found to significantly block 3-NP-induced impairment of glutathione homeostasis and reduce lipid peroxidation and DNA oxidative damage in the striatum. Moreover, it was found to improve motor performance and extend survival in the mouse model of Huntington’s disease. These results suggest that the combination of co enzyme Q10 and creatine hold potential as therapeutic agents in the treatment of neurodegenerative conditions such as Parkinson’s disease and Huntington’s disease.