6% of Mayo MSA cases also had CTE

There was an interesting paper on MSA brain research published this week that a lot of BSN families played a role in.

Researchers examined 139 MSA brains donated to Mayo Jacksonville. They were looking for evidence of CTE, chronic traumatic encephalopathy. That’s the neurodegenerative disorder developed by football players, soccer players, and other participants in contact sports. They found 8 cases (6%) had CTE pathology. All of the 8 cases were men, and 4 had a documented history of playing contact sports. The median age at death in MSA with CTE was younger than in MSA without CTE. The abstract is below.

About 25% of these 139 MSA brains were donated to the Mayo Clinic as a result of the generosity of MSA families who were assisted by Brain Support Network in the brain donation process!




J Neuropathol Exp Neurol. 2016 Aug 18. [Epub ahead of print] Chronic Traumatic Encephalopathy Pathology in Multiple System Atrophy.
Koga S, Dickson DW, Bieniek KF.

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder associated with repetitive traumatic brain injury. Multiple system atrophy (MSA) is a Parkinsonian disorder that can result in repetitive falls with associated head trauma. We hypothesized that patients with neurodegenerative disorders like MSA could develop CTE pathology. Therefore, we assessed CTE pathology in 139 MSA cases in our brain bank. Sections from convexity cerebral cortices were screened by immunohistochemistry with anti-phospho-tau antibody. For cases with suggestive CTE pathology, further sections of basal forebrain and hippocampus were immunostained. Consensus criteria were used to make the diagnosis of CTE and aging-related tau astrogliopathy (ARTAG) was differentiated from CTE pathology. Pertinent clinical information was derived from the available records and online searches. Of the 139 MSA cases, 8 (6%) had CTE pathology and 10 (8%) had ARTAG pathology. All 8 cases with CTE were male and 4 of them had a documented history of contact sports. The median age at death in MSA with CTE was younger than in MSA without CTE or MSA with ARTAG (60, 67, and 74 years, respectively; p = 0.002). Even without a known history of contact sports or head trauma, a small subset of cases with MSA had CTE pathology.

PubMed ID#: 27543120